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De novo synthesis occurs in a two-step reaction catalyzed by two separate enzymes, glutamine-cysteine ligase (GCL) and glutathione synthase (GS), as shown in Figure 1

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Differential Diagnosis, Investigations, and Treatment Upon admission, this patient's differential diagnosis included drug‐induced liver injury (DILI) versus undifferentiated shock leading to perfusion‐related ischemic hepatitis